Current Research Projects

Research

Our current and recent research projects exemplify the breadth of research done by our faculty members.

Here is the list of current peer-reviewed grants. 

Anthes M (PI), Jumah NA, Curiel L. MR-HIFU Training Workshop. Northern Ontario Academic Medical Association Clinical Innovation Opportunities Fund. $33,555. April 2014 – March 2016.

Baker A (PI), Librach CL (Co-PI). Human umbilical cord perivascular cell (HUCPVC) therapy for traumatic brain injury: targeting the neurovascular unit. Physicians Services Incorporated (PSI). $160,500. June 2015 – May 2017.

Berger H (Co-PI), Feig D (Co-PI), Lipscombe L (Co-PI) Bocking A, Birken C, Maguire J, Halperin I, Mukerji G, Melamed N, Wolfs M. BBDC Diabetes in Pregnancy Cohort Study. Banting and Best Diabetes Centre (BBDC). $247,208. April 2015 – March 2017.

Bernardini MQ (PI), Ferguson SE, Rosen B, Murphy J, Laframboise S, May T, Dodge J, Kamel-Reid S, Stockley T, Oza A, Rodin G, Virtanen C, McCuaig J, Tone A. The Princess Margaret Cancer Centre Prevent Ovarian Cancer Program. Princess Margaret Foundation. $976,110. May 2015 – July 2017.

Brown T (PI). Novel functions of nuclear receptor coactivator 4 at the mitotic apparatus. Natural Sciences and Engineering Research Council of Canada (NSERC). Discovery Grant. $150,000. April 2011 - April 2016.

Brown T (PI), Rosen B (PI), Allen L, Beranrdini MQ, Colgan T, Ferguson SE, Greenblatt E, Murphy J, Tone A, Virtanen C. Sustained ovulation-associated inflammatory signaling in fallopian tube epithelium as a predisposing factor of serous carcinoma. Canadian Institutes of Health Research (CIHR). $483,753. September 2013 – August 2016.

Burchell A (PI), Loutfy MR, Yudin MH. Improving access for Papanicolaou testing for women with HIV through nursing scope optimization: a pilot project. Women’s College Hospital, Innovation Funds Grant. $30,000. 2015 – 2016.

Caniggia I (PI), Nevo O, Post M. The role of Bcl-2 family members in regulating placental cell fate. Canadian Institutes of Health Research (CIHR) Operating Grant. $795,820. April 2014 – March 2019.

Caniggia I (PI). The Dynamic Role of the Oxygen/TGFß Axis in Regulating Sphingolipid Metabolism during Placental Development. Natural Sciences and Engineering Research Council (NSERC) Discovery Grant. $150,000. April 2015 – March 2020.

Casper RF (PI), Juriscova A. Characterization of the bioenergetics and metabolic function of mitochondria isolated from oocyte precursor stem cells. Canadian Institutes of Health Research (CIHR), Operating Grant: Industry-partnered Collaborative Research. $911,700. April 2015 – March 2020.

Casper RF (PI), Shapiro CM, Rahman S. Ameliorating affective disorder induced by circadian rhythm disruption. Canadian Institutes of Health Research (CIHR). Operating Grant. $430,821. October 2010 – March 2016.

Christoffersen-Deb A (PI), Ruhl L, Songok J. Chamas for Change: Building Adult Capabilities to Safeguard Children’s Developmental Potential through Mother-Child Clubs in Kenya. Grand Challenges Canada. Saving Brains Seed grant. $250,000. May 2015 – November 2016.

Connelly PW (PI), Hanley AJ (PI), Retnakaran R (PI), Sermer M (PI), Zinman B (PI). Postpartum Progression to Type 2 Diabetes in Women with Recent Glucose Intolerance in Pregnancy: Pathophysiology, Biomarkers and Clinical Implications. Canadian Institues of Health Research (CIHR). $685,470. July 2012 – September 2017.

Derzko C (PI), Jenkins D (Co-PI). A retrospective chart review to assess the effects of a high soy protein diet on endometrial thickness and vaginal maturation index. Canada Research Chair Discretionary Funds). $80,000. April 2015 – March 2017.

Fehlings M (PI), Nagy A. An examination of the therapeutic impact of human induced pluripotent stem cell-derived neural precursor cells in cervical spinal cord injury. Wings for Life Spinal Cord Research Foundation Grant. $114,463. July 2014 – July 2016.

Fehlings M (PI), Nagy A, Morshead C, Shoichet M, Tator C, van der Kooy D. Repair and regeneration of the injured cervical spinal cord: An integrated translationally oriented team grant. Krembil Foundation Grant. $1,500,000. May 2015 – May 2018.

Feig D (PI), Armson BA, Asztalos E, Fantus IG, Hamilton JK, Hagg AM, Lee SK, Lipscombe L, Murphy KE, Ohlsson A, Ryan EA, Tomlinson GA, Zinman B. MiTy Kids (Metformin in Women with Type 2 Diabetes in Pregnancy Kids Trial). Canadian Institutes of Health Research (CIHR), Clinical Trial. $1,299,000. October 2012 – September 2018.

Ferguson SE (PI), Classen C (PI), Barbera L, Chivers M, Urowitz S, Wiljer D. An online support group for sexual distress due to gynecologic cancer: A randomized study. Canadian Institutes of Health Research (CIHR). $727,860. July 2012 – July 2016.

Fowler R (PI), Aoyama K, Hladunewich M, Labinsky S, Ray J, Scales DC, Shah P, Seaward PG. Regional and temporal variations in incidence, prevalence and outcomes of critical illeness among pregnant and post partum women and newborns in Canada. Canadian Institutes of Health Research (CIHR). $46,415. April 2012 – June 2017.

Geary M (Co-PI), Freire-Lizama T (Co-PI), Berger H, Adams S, Barrett J, Campbell D, Sgro M, Maguire J, Ray J, Ruiter J. The Role of Simulation training on Shoulder Dystocia management and its effects on the incidence of Brachial Plexus Injury. Academic Funding Program Innovation Funds. $20,856. April 2015 – April 2016.

Greenblatt EG (PI), Elliott JE, Brown T, Shapiro H. Non-invasive genomic analysis of human endometrial receptivity in women with polycystic ovarian syndrome. Mount Sinai Hospital, Resident Research Grant. $10,000. July 2014 - June 2017.

Howell D (PI), Buick C, Murphy J. Understanding Adherence Behaviours in Women with Precancerous Cervical Abnormalities Diagnosed with High-risk Human Papillomavirus (HPV). Princess Margaret Cancer Centre Founation. $29,505. January 2013 – January 2016.

Jaeggi E (PI), Blom N, Carvalho J, Cuneo B, Gembruch U, Kelly E, McCrindle B, Moon-Grady A, Offringa M, Ryan G, Saul J.  Fetal Atrial Flutter & Supraventricular Tachycardia (FAST) Therapy Trial: Proposal of an International Registry and Randomized Controlled Trial (RCT). Canadian Institutes of Health Research (CIHR), Human Development, Child and Youth Health. $611,000. March 2014 - May 2019.

Jumah NA (PI), Kahan M, Bruni T, Bishop D. Nortwestern Ontario Strategies for Opioid Dependence in Pregnancy. Northern Ontario Academic Medical Association. $50,020. April 2014 – March 2016.

Jumah NA (PI), Richardson L, Wanakamik Y, Armstrong T. Hearing Our Voices: An Indigenous Women’s Reproductive Health Curriculum. Northern Ontario Academic Medical Association. $50,000. April 2015 – March 2017.

Kewayosh A, Rabeneck L, Tinmouth J (Co PIs), Baxter NN, Borkhoff CM, Deber RSB, Dobrow M, Gesnik D, Jackson SF, Jumah NA, Llovet DN, Lofter AK, Marrett LD, Mackinnon ML, Paszat LF. Improving cancer screening among First Nations and Métis. Canadian Institutes of Health Research (CIHR) Partnerships for Health System Improvement Grant. $562,491. July 2013 – June 2017.

Kingdom J (PI), Cox B. Placental response to heparin: implications for the prevention of pre-eclampsia. Canadian Institutes of Health Research (CIHR), Operating Grant. $521,660. October 2012 - September 2016.

Kingdom J (PI), Cox B. Villious Trophoblast Turnover. Canadian Institutes of Health Research (CIHR), Operating Grant. $719,235. March 2014 - February 2019.

Kislinger T (PI), Ailles LE, Bernardini MQ, Blaise C. A Novel Biomarker Discovery Strategy Combining Primary Tumour Xenograft Models and Glyco-Capture of Secreted Proteins. Canadian Institutes of Health Research (CIHR). $480,264. May 2014 – April 2017.

Li RK (PI), Librach CL. Pre-clinical development of a novel umbilical cord perivascular cell-based therapy to prevent heart failure. Ministry of Research Innovation. Ontario Research Fund Excellence. $4,231,731. February 2015 – January 2018.

Lim KI (PI), von Dadelszen P (PI), Ansermino JM, Audibert F, Bujold E, Chanoine JP, Davidge ST, Lalji S, Magee LA, Piedboeuf B, Robinson WP, Seaward PG, Singer J, Synnes AR. The Canadian STRIDER Trial: Sidenafil for dismal prognosis IUGR. Canadian Institutes of Health Research (CIHR), Operating Grant. $630,246. October 2014 – September 2019.

Lo K (PI), Librach CL (Co-PI), Moskovtsev S, Gauthier-Fisher A, Diamandis C, Drabovich A. Changing the Paradigm for Male fertility Treatment - Standardized Automated Platform for Sperm Retrieval. AHSC. AFP Innovation foundation. $166,718. April 2015 – March 2017.

Loutfy MR (PI), Becker M (PI), Bourassa C (PI), Bruce SG (PI), Greene S (PI), Kaida AK (PI), de Pokomandy A, (PI) Angel JB, Antoniou T, Archibald CP, Bauer GR, Beaver K, Benoit AC, Brophy JC, Brotto LA, Buhler S, Burchell AN, Carter AJ, Conway TPM, Cooper CL, Cotnam J, Hankins CA, Hart TA, Hogg RS, Ion A, Jaworsky DW, Kennedy VL, Keshmiri R, Kestler M, Khan S, Lacombe-Duncan A, Lloyd-Smith EM, Logie CH, Martin C, Mcquarrie SL, Miller C, Money DM, Muchenje M, Nicholson V, O’Brien KK, O’Brien N, O’Neill TJ, Ogilvie GS, Otis J, Patterson SE, Payne MJ, Pick N, Poitras ML, Prentice T, Rachlis AR, Roth E, Rourke SB, Rueda S, Skinner SJ, Smaill FM, Sullivan TM, Summers M, Tharao WE, Thomas-Pavanel JL, Tremblay CL, Walmsley SL, Whitebird W, Worthington CA, Yudin MH, Zoccole A. Canadian HIV women’s sexual and reproductive health cohort study phase 2: addressing priorities in women-centred HIV care across the life course. Canadian Institutes of Health Research (CIHR), Transitional Operating Grant. $433,351. July 2015 – June 2020.

Loutfy MR (PI), Kaida AK (PI), De Pokomandy A, Hogg RS, Anema A, Angel J, Baril J, Brophy J, Brotto L, Gahagan J, Hankins C, Kaushic C, Klein M, Leonard L, Lima V, Lloyd-Smith E, Miller C, Money DM, Ogilvie G, Palmer A, Pick N, Raboud J, Rachlis A, Roth E, Rouleau D, Rourke S, Tharao W, Tremblay C, Trottier B, Trottier S, Tsoukas C, Walmsley S, Yudin MH. Canadian HIV Women and Reproductive Health Cohort Study, a Canadian Observational Cohort (CANOC) Affiliated Study. Canadian Institutes of Health Research (CIHR) Operating Grant. $1,192,490. 2011 – 2016.

Loutfy MR (PI), Serghides L (PI), Yudin MH (PI), Angel J, Bayoumi A, Bitnun S, Brophy J, Calzavara L, Carvalhal A, Greene S, Gruslin A, Hamilton G, LaPorte C, Lye S, Murphy K, Newmeyer T, Raboud J, Rachlis A, Ralph E, Rosenthal K, Shapiro H, Shynlova O, Silverman M, Smaill F, Smith M, Walmsley S, Wobeser W. Interdisciplinary HIV pregnancy research group: care and research to optimize HIV-positive women’s health during preconception, pregnancy and motherhood. $900,000. April 2011 – March 2017.

Lye SJ (PI), Adams-Waldorf K, Gravett M, Shynlova O. Targeting Leukocyte Activation to Prevent Preterm Labor (Preterm Birth Initiative). Burroughs Wellcome Fund, Operating Grant. $600,000 USD. June 2014 – March 2018.

Lye SJ (PI), Bocking AD, Connor KL, Maxwell C. Host-microbe Genomic Approaches to Understanding Obesity and Diabetes in Pregnancy. McLaughlin Centre (Accelerator Grant). Operating Grant. $65,000. May 2015 – April 2016.

Lye SJ (PI), Bocking AD, Kim SO, Shynlova O. Prevention of Preterm Birth: Targeting Inflammatory Pathways. March of Dimes, Operating Grant. $300,000 USD. March 2014 – February 2017.

Maheu C (PI), Lebel S (PI), Courbasson C, Singh M, Catton P, Bernstein L, Benea A, Jolicoeur L, Lefebvre M, Harris C, Agnihotram RKV, Sidanie S, Ferguson SE, Muraca L. Efficacy of a cognitive-existential intervention to address fear of recurrence in women with cancer: a randomized controlled clinical trial. Canadian Cancer Society Research Institute (CCSRI). $300,000. February 2014 – February 2017.

Maguire J (PI), Berger H, Sgro M, Bocking A, Persaud N, Ray J. Improving the cardiometabolic health of mothers and young children. Academic Funding Program Innovation Funds. $41,603. April 2014 – April 2016.

McDonald SD, Giglia L, Thabane L, Maxwell C. A Clinical Care Pathway for Obese Pregnant Women: A Pilt Cluster Randomized Control Trial in Obstetrics Midwifery and Family Medicine Clinics. Hamilton Academic Health Sciences Organization. $188,631. April 2015 – March 2017.

Miller SP (PI), Seed M (PI), Blaser S, Brant R, Chau V, Hickey E, Ly L, Kingdom J, Macgowan C, Schwartz S, Sled J. Cardiovascular Physiology and Brain Development in Newborns with Congenital Heart Disease. Canadian Institutes of Health Research (CIHR). $1,377,444. July 2015 – June 2021.

Murphy KE (PI), Raboud J, Serghides L, Silverman M, Yudin MH, Loutfy M, Walmsley S, Papp E. The ProSPAR Study: Progesterone Supplementation for HIV Positive Pregnant Women on Antiretrovirals. Canadian Foundation for AIDS Research (CANFAR). $80,000. July 2014 – June 2017.

Nagy A (PI). Tier 1 - Canada Research Chair in Stem Cells and Regeneration. Government of Canada. $1,400,000. October 2014 – October 2021.

Nagy A (PI), Rogers IM, Rossant J, Woodgett J, Wrana J, Zandstra P. Molecular pathways of reprogramming - from discovery to novel therapeutics. Ontario Research Fund - Global Leadership in Genomics and Life Sciences (ORF-GL2). $9,058,021. April 2010 – April 2016.

Nagy A (PI), Tremblay J, Ellis J. Directing cellular identity to move towards progenitor cell therapies. Canada-Japan, Canadian Epigenetics, Environment and Health Research Consortium (CEEHRC) Teams in Epigenetics of Stem Cells. $2,000,000. April 2013 – March 2018.

Narod S, Casper RF, Kotsopoulos J, Wheeler AR. The physiological impact of postmenopausal oophorectomy on hormone levels in women with BRCA1 mutation.Canadian Institutes of Health Research (CIHR) - NSERC partnered. Collaborative Health Research Projects. $412,769. April 2012 – March 2016.

Oko, R (PI), Librach CL. PAWP, a candidate sperm-borne oocyte activating factor. Canadian Institutes of Health Research (CIHR). $690,480. July 2012 – June 2017.

Plante M (PI), Ferguson SE, Kwon J, Brotto L, Fyles T, Meyer R, Craighead P, Gavin S, Arseneau J, Atri M. The SHAPE trial: Simple Hysterectomy And Pelvic node dissection in Early cervix cancer. Canadian Institutes of Health Research (CIHR). $2,200,000. September 2012 – August 2020.

Rosen B (PI), May T (Co-PI). Surgical Outcomes in Sites; Demonstrating Improved Outcomes of Synaptic Surgery Reporting. Candian Partnership against cancer. $250,000. June 2015 – May 2016.

Rossant J (Canadian PI), Nagy A, Zandstra P, van der Kooy D, Stanford B, Keller G, Keating A, Postovit, May M (Canadian CIs) Deng H (China PI), Wang C, Pei X, Zhao C, Zhou Q, Li L (China CIs) The Ontario-China stem cell research and commercialization partnership. Ministry of Economic Development and Innovation (MEDI) Ontario-China Research and Innovation Fund (OCRIF), Ministry of Science and Technology (MST). $6,200,000. April 2013 – March 2018.

Roth D (PI), Zlotkin S, Morris S, Weksburg R, Willan A, Adeli K, Murphy KE, Shah P, Gergolas E, Al Mahmud A, Ahmud T, Islam M, Shah R, Baqui A. Prenatal vitamin D trial in Bangladesh. The Bill and Melinda Gates Foundation. $1,999,993. July 2012 – June 2017.

Saravanan P (PI), Waugh N, Stallard N, Raymond N, Kimani P, Pastakia S, Christoffersen-Deb A, Onyango B, Mohan V, Ranjit A, Mohan D, Ram U. Ethnic specific risk stratification in early pregnancy for identifying mothers at risk of gestational diabetes mellitus in India and Kenya. Medical Research Council UK. Research Grant. $1,193,110.77. July 2015 – July 2018. 

Seed M (PI), Jaeggi E, Miller S, Kingdom J, Macgowan C, Yoo SJ, Kelly E, Blaser S, McCrindle B. Early detection and neurodevelopmental outcome in late onset intrauterine growth restriction. SickKids Foundation/Canadian Institutes of Health Research (CIHR) new investigator. $298,390. October 2013 – March 2016.

Sefton M (PI), Van der Kooy D, Zandstra P, Rogers IM. Determine appropriate biomaterial to be used as a delivery system for stem cells in a wound healing setting. Ontario Research Fund (ORF). $300,000. May 2013 – March 2016. 

Serghides L (PI), Kibschull M, Papp E, Shynlova O, Silverman M. HIV antiretrovirals and their impact on sex steroids during pregnancy; a potential mechanism for the increased adverse pregnancy outcomes in women with HIV. Canadian Institutes of Health Research (CIHR), Operating Grant. $209,152. October 2013 – September 2018. 

Serghides L (PI), Murphy KE, Walmsley S, Raboud J, Silverman M, Loutfy MR, Yudin MH. The ProSPAR study: progesterone supplementation for HIV-positive pregnant women on antiretrovirals. Canadian Foundation for AIDS Research (CANFAR). $131,808. 2014 – 2016.

Sled JG (PI), Macgowan C (Co-PI), Adamson SL, Kingdom J, Seed M. Advanced MRI methods for early detection and characterization of placental dysfunction and the monitoring of therapy. Canadian Institutes of Health Research, Operating Grant. $470,586. October 2013 – September 2016.

van der Kooy D (PI), Nagy A, Morshead C, Fehlings M, Peterson A. Testing Neural Precursors as Mediators and Facilitators of Constraint Induced movement therapy in Cerebral Palsy. Neurodevelopment Network Inc. (NeuroDevNet), Networks of Centres of Excellence Cycle II Renewal. $320,001. April 2015 – June 2017.

Yudin MH (PI), Khan S, MacGillivray J, Bitnun A, Read S. Infant feeding in HIV: knowledge, experiences and feasibility survey. St. Michael’s Hospital AFP Innovation Funds. $28,912. 2015 - 2017.

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