Research Interestspelvic organ prolapse
Dr. Alarab graduated from Medical School Baghdad University, following which she completed her training in Obstetrics and Gynecology in Ireland and UK, receiving the membership of the Royal College of Obstetricians and Gynecologist (UK) and the Royal College of Physicians of Ireland.
She then completed a fellowship in Urogynecology and Reconstructive Pelvic Surgery at Mount Sinai Hospital, University of Toronto, during which she developed an interest in the etiology of pelvic organ prolapse in young women and that was the subject of her Master of Science thesis towards an MSc degree with the Institute of Medical Science, University of Toronto.
I have started a basic science research program within the division of Urogynecology and Reconstructive Pelvic Surgery. It is the first of its kind in Canada to examine the extra cellular matrix of vaginal tissue of women with pelvic organ prolapse and to study the molecular biology of this disease using the gene and protein expression profile. This program has evolved and has both an national and international reputation wherein fellows and postgraduate students have been utilizing this venue in their fellowship training and in achieving higher post graduate degrees. Our work has been acknowledged both locally and Internationally. Mount Sinai is Known for this specific research. In addition, our work has been awarded peer-reviewed publications and presentations on the international level.
2013 Jun - 2014 Jul ~ Co-Principal Investigator. Menopause-related hormonal deprivation in the presence of mechanical stretch influence collagen and elastin remodelling in vaginal wall of postmenopausal women: potential implications for the development of Pelvic Organ Prolapse. University of Toronto-Faculty of Medicine. PI: Shynlova, Oksana. Alarab, May. 20,000 CAD.
2012 Jun - 2013 Jun ~ Principal Investigator. Leukocyte Infiltration and Cytokine Expression in the Vaginal Tissue of Women with and without Pelvic Organ Prolapse (pilot project). Mount Sinai Hospital Research Fund. Mount Sinai Hospital. Collaborator(s): Shynlova, Oksana, Drutz, Harold. 6,000 CAD.
2011 Jul - 2012 Jun ~ Principal Investigator. Expression of Procollagen N Proteinase in the Vaginal Tissue of Women with and without Pelvic Organ Prolapse. Mount Sinai Hospital. Mount Sinai Hospital Research Fund. 10,000 CAD.
2010 Jul - 2011 Jul ~ Co-Principal Investigator. Expression of Procollagen C Proteinase in the Vaginal Tissue of Women with and without Pelvic Organ Prolapse. Mount Sinai Hospital and University Health Network. Research Fund, Department of Obstetrics and Gynecology. 8,000 CAD.
2010 Jan - 2011 Dec ~ Principal Investigator. Expression of Modulators of Collagen and Elastin Remodeling in Vaginal Tissue of Premenopausal Women with Severe Pelvic Organ Prolapse in the secretary phase. Physicians Services Incorporated Foundation (The) (PSI). 28,600 CAD.
2009 Jan - 2009 Dec ~ Principal Investigator. Expression of Smooth Muscle Contractile Machinery Proteins in the Vaginal Tissue of Women with and without Pelvic Organ Prolapse. Physicians Services Incorporated Foundation (PSI). 16,400 CAD.
2009 Jan - 2009 Dec ~ Principal Investigator. Expression of modulators of collagen and elastin remodeling in vaginal wall of postmenopausal women with severe pelvic organ prolapse in the proliferative phase of the menstrual cycle. University of Toronto. Faculty of Medicine Dean’s Fund New Staff Award. 10,000 CAD.
2006 Jul - 2007 Jun ~ Principal Investigator. Extra Cellular Matrix remodelling in pelvic tissue with and with out pelvic organ prolapse. Mount Sinai Hospital. Mount Sinai Hospital Research funds. Collaborator(s): HP Drutz, S Lye. 10,000 CAD.
Publications and Awards
Medel S., Alarab M., Kufaishi H., Drutz H. and Shynlova O. Attachment of primary vaginal fibroblasts to absorbable and non-absorbable implant materials coated with Platelet Rich Plasma: potential application in Pelvic Organ Prolapse surgery. Female Pelvic Medicine & Reconstructive Surgery. 2015 Jan. In Press.
Zebede S. Lovatsis D, Alarab M, Drutz H. Prevalence of Obstructive Sleep Apnea detected by the Berlin Questionnaire in patients with nocturia attending a Urogynecology Unit. International Urogynecology Journal. 2014 Dec 2. In Press.
Kufaishi H, Alarab M, Drutz H, Lye S, Shynlova O. Comparative characterization of vaginal fibroblast cells from premenopausal women with and without severe organ prolapse. Submitted to Reproductive Sciences. Reproductive Sciences. 2014 Jun. In Press.
Alarab M, Kufaishi H, Drutz H, Lye S, Shynlova O. Expression of extracellular matrix-remodeling proteins is altered in vaginal tissue of premenopausal women with severe pelvic organ prolapse. Reproductive Sciences. 2014 Jun;21(6):704-15. Reprod Sci. 2014 Jun;21(6):704-15. doi: 10.1177/1933719113512529. Epub 2013 Dec 16.
S Hassonah S, Medel S, Lovatsis, D, Drutz HP, Alarab M. Outcome of laparoscopic two-team sling procedure, Tension-free Vaginal Tape and transobturator tape insertion in women with recurrent stress urinary incontinence. J Obstet Gynaecol Canada. 2013 Nov. J Obstet Gynaecol Can. 2013 Nov;35(11):1004-9.
Oksana Shynlova, PhD, Maria MA. Bortolini, MD, Alarab M, MD. Genes responsible for vaginal extracellular matrix metabolism are modulated by women’s reproductive cycle and menopause. International Brazilian Journal of Urology. 2013 Mar. Int Braz J Urol. 2013 Mar-Apr;39(2):257-67. doi: 10.1590/S1677-5538.IBJU.2013.02.15.
P Diamond, S Hassonah, M Alarab, D Lovatsis, HP Drutz. The prevalence of detrusor overactivity amongst patients with symptoms of overactive bladder: a retrospective cohort study. Int Urogynecol J. Int Urogynecol J. 2012 Nov;23(11):1577-80.
Miranda V, Alarab M, Pineda P, Lovatsis D, Murphy K, Drutz HP. Efficacy and safety of Tension Free Vaginal Tape (TVT) compared with Trans Obturator Tape (TOT) among obese women with stress urinary incontinence: A retrospective cohort study. Int Urogynecol J Pelvic Floor Dysfunct. J Obstet Gynaecol Can. 2012 Aug;34(8):755-9.
Best C, Drutz H, Alarab M. Obstetrical Anal Sphincter Injuries: A Survey of Clinical Practice among Canadian Obstetricians. J Obstet Gynecol Canada. 2012 Aug. J Obstet Gynaecol Can. 2012 Aug;34(8):747-54.
Khoshbakht N, Alarab M, Lovatsis D. Stress Urinary Incontinence Six Months Post Laparoscopic Sacrocolpopexy. J Obstet Gynaecol Canada. J Obstet Gynaecol Can. 2012 Jul;34(7):653-6.
Bortolini MA, Shynlova O, Drutz HP, Girão MJ, Castro RA, Lye S, Alarab M. Expression of Genes encoding smooth muscle contractile protein in vaginal tissue of women with and without pelvic organ prolapse. Neurourol Urodynamic. Neurourol Urodyn. 2012 Jan;31(1):109-14. doi: 10.1002/nau.21175.
Miranda V, Alarab M, Murphy K, Pineda R, Drutz H, Lovatsis D. Randomized controlled trial of cystocele plication risk: a pilot study. J Obstet Gynaecol Canada. J Obstet Gynaecol Canada 2011;33(11): 1146-9.
Bortolini MA, Shynlova O, Drutz HP, Girão MJ, Castro RA, Lye S, Alarab M. Expression of bone morphogenetic protein-1 in vaginal tissue of women with severe pelvic organ prolapse. Am J Obstet Gynecol. Am J Obstet Gynecol. 2011 Jun;204(6):544.e1-8.
Alarab M, Bortolini MAT, Drutz H, Lye S, Shynlova O. Altered Expression of Lysyl Oxidase Enzyme Family in Vaginal tissue of Premenopausal Women with severe Pelvic Organ Prolapse. Int Urogynecol J Pelvic Floor Dysfunct. Int Urogynecol J. 2010 Nov;21(11):1397-404.
Bortolini MAT, Lovatsis D, Drutz HP, Alarab M. Vaginal delivery and pelvic floor dysfunction: current evidence and implications for future research. Int Urogynecol J Pelvic Floor Dysfunct. Int Urogynecol J. 2010 Aug;21(8):1025-30. doi: 10.1007/s00192-010-1146-9.